Expression of recombinant proteins in attenuated bacteria

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 1/21 (2006.01) A61K 39/112 (2006.01) C07K 14/33 (2006.01) C12N 15/74 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2099841

An attenuated bacterium which is capable of expressing a heterologous protein, the expression of the heterologous protein being under the control of a promoter whose activity is induced by anaerobic conditions, can be used as a vaccine. A suitable promoter is the nirB promoter.

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