Expression of specific immunogens using viral antigens

Details Expression of specific immunogens using viral antigens Expression of specific immunogens using viral antigens

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 39/00 (2006.01) A61K 39/295 (2006.01) A61K 39/39 (2006.01) C07K 14/11 (2006.01) C07K 14/16 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/44 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2084180

ABSTRACT OF THE DISCLOSURE Chimeric DNA fragments are provided which include a nucleotide sequence substantially the same as that which codes for the HA surface protein of an influenza A virus having five immunodominant antigenic sites, wherein a nucleotide sequence substantially the same as that which codes for a foreign epitope is inserted into the nucleotide sequence of an antigen- ic site. Corresponding chimeric peptides, expression vectors, and transformed hosts are provided as well. These peptides are useful in providing vaccines against the respective antigens and in test kits to detect the exposure to such antigens. Additionally, these peptides or their corresponding antibodies are useful in methods of treatment and prevention of the manifestations of exposure to these antigens, including immuno- therapy.

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