C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/81 (2006.01)
Patent
CA 2713993
Streptomyces and Bacillus host cells comprising a recombinant nucleic acid encoding a fusion protein containing a signal sequence and a Streptomyces subtilisin inhibitor (SSI) protein are provided, as well as methods of producing SSI protein using those cells. In certain embodiments, the host cell is a Streptomyces host cell and the signal sequence is a celA signal sequence. In other embodiments, the host cell is a Bacillus host cell that has a genome that contains inactivated protease genes.
La présente invention concerne des cellules hôtes de Streptomyces et de Bacillus comportant un acide nucléique recombinant codant pour une protéine hybride contenant une séquence signal et une protéine d'inhibition de la subtilisine de Streptomyces (SSI), ainsi que des procédés de production de protéine d'inhibition de la subtilisine de Streptomyces mettant en uvre lesdites cellules. Selon certains modes de réalisation, la cellule hôte est une cellule hôte de Streptomyces et la séquence signal est une séquence signal ce1A. Selon d'autres modes de réalisation, la cellule hôte est une cellule hôte deBacillus qui présente un génome contenant des gènes de protéase inactivés.
Fox Bryan P.
Wang Huaming
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Danisco Us Inc.
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