C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/86 (2006.01) A61K 35/18 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 15/49 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2172073
There is described a recombinant nucleic acid vector for the delivery of nucleic acid to a host organism comprising a transcription unit encoding a transdominant negative mutant of a viral gene product which has been selected substantially to avoid a negative biological effect in the host under the control of a DNA sequence active in cells normally infected by a virus which is effective to confer constitutive tissue-specific, integration site-independent, copy-number dependent expression of the transcription unit.
L'invention concerne un vecteur d'acide nucléique recombiné destiné à l'apport d'acide nucléique à un organisme hôte comprenant une unité de transcription codant un mutant négatif transdominant d'un produit génique viral choisi notamment pour éviter un effet biologique négatif chez l'hôte sous le contrôle d'une séquence d'ADN active dans des cellules normalement infectées par un virus, laquelle est efficace pour conférer une expression de l'unité de transcription qui soit spécifique aux tissus constitutifs, indépendante du site d'intégration et dépendante du nombre de copies.
Abraham David
Craig Roger Kingdon
Dzierzak Elaine
Grosveld Franklin Gerardus
Cobra Therapeutics Limited
Kirby Eades Gale Baker
Medical Research Council
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