Expression system for human brain-specific voltage-gated...

Details Expression system for human brain-specific voltage-gated... Expression system for human brain-specific voltage-gated...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2474751

Isolated nucleic acids encoding human SCN1A polypeptides, recombinantly expressed and isolated human SCN1A polypeptides, heterologous expression systems for recombinant expression of human SCN1A polypeptides, assay methods employing the same, and methods and compositions for modulation of sodium channel function.

L'invention concerne des acides nucléiques isolés codant des polypeptides SCN1A humains, des polypeptides SCN1A humains isolés et exprimés de manière recombinante, des systèmes d'expression hétérologue permettant d'obtenir une expression recombinante de polypeptides SCN1A humains, des procédés de dosage utilisant ce système, et des procédés et des compositions pour la modulation de la fonction du canal sodique.

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