C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/70 (2006.01) C07K 14/775 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12N 15/12 (2006.01) C12N 15/71 (2006.01)
Patent
CA 2150928
The invention relates to an expression system giving high extracellular production of apolipoprotein AI-M (Milano) using E. coli and comprises a plasmid carrying an origin of replication, an inducible promoter sequence, a DNA sequence coding for a signal peptide, a DNA sequence coding for apolipoprotein AI-M, and a transcription terminator. The invention also relates to a method of producing apolipoprotein AI-M using the expression system.
Abrahmsen Lars
Holmgren Erik
Kalderen Christina
Lake Mats
Mikaelsson Asa
Esperion Therapeutics Inc.
Kabi Pharmacia Ab
Smart & Biggar
LandOfFree
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