C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.102, 195/1
C12N 15/66 (2006.01) C07K 16/24 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/00 (2006.01) C12N 15/65 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2008259
ABSTRACT The present invention relates to an expression system for producing chimeric antibodies. The expression system includes vectors that contains the entire human genomic constant region of a immunoglobulin heavy and/or light chain and is adaptable for insertion, without mutagenesis, of a nonhuman antibody variable region. The resulting expression vector includes the entire human genomic constant region and the entire nonhuman variable region lacking tissue specific promoter and/or enhancer regions normally associated with genomic DNA. Chimeric monoclonal antibodies to interleukin-2 receptor and tumor neucrosis factor are examples of chimeric monoclonal antibodies that can be produced by this method. MTI 210.1
Borden Ladner Gervais Llp
Molecular Therapeutics Inc.
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