C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 48/00 (2006.01) C07K 14/025 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/69 (2006.01) C12N 15/85 (2006.01)
Patent
CA 2294119
A novel method is described for expressing biologically functional therapeutic proteins without host cell toxicity. This method takes advantage of the surprising replication activating ability of the 107/402-T antigen. The invention also provides expression vectors, human cells, and fusion proteins for practicing the method. The invention thus provides the art with an expression system for therapeutic proteins which is useful to the pharmaceutical and biotechnology industries.
Cette invention se rapporte à un nouveau procédé servant à exprimer des protéines thérapeutiques biologiquement fonctionnelles sans toxicité envers les cellules hôtes. Ce procédé tire profit de la surprenante capacité d'activation de réplication de l'antigène 107/402-T. Cette invention présente également des vecteurs d'expression, des cellules humaines et des protéines de fusion permettant la réalisation de ce procédé. Cette invention offre ainsi au spécialiste un système d'expression pour des protéines thérapeutiques qui est utile pour l'industrie pharmaceutique et pour l'industrie de la biotechnologie.
Brunovskis Peter
Cooper Mark J.
Case Western Reserve University
Sim & Mcburney
LandOfFree
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