C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
530/13, 195/1.2,
C12N 15/76 (2006.01) C07K 14/535 (2006.01) C12N 9/52 (2006.01) C12N 15/27 (2006.01) C12N 15/62 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1295567
A B S T R A C T A gene expression system is used to produce heterologous biologically active proteins, in particular bioactive granulocyte, macrophage-colony stimulating factor ("GM-CSF"), secreted from a host selected from the Streptomyces genera. The gene expression system includes a regulatory nucleotide sequence linked to a second nucleotide sequence encoding the heterologous protein. The regulatory sequence, encodes a peptide which directs the secretion of the heterologous protein in bioactive form from a host selected from the Streptomyces genera. The regulatory sequence includes a signal sequence and a promoter sequence. The second nucleotide sequence, which encodes GM-CSF or a biologically active derivative of GM-CSF, may be either natural or synthetic. The product of this invention is disulphide-bonded, non-glycosylated, oxidized, therapeutically useful GM-CSF from a host selected from the Streptomyces genera.
572956
Garvin Robert T.
Malek Lawrence T.
Blake Cassels & Graydon Llp
Cangene Corporation
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