Expression systems utilizing autolyzing fusion proteins and...

Details Expression systems utilizing autolyzing fusion proteins and... Expression systems utilizing autolyzing fusion proteins and...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/44 (2006.01) C07H 21/04 (2006.01) C07K 1/22 (2006.01) C07K 14/54 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/18 (2006.01) C12N 9/02 (2006.01) C12N 9/50 (2006.01) C12N 15/53 (2006.01) C12N 15/57 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2153720

The present invention provides expression systems for exogenous polypeptides wherein the polypeptide is expressed as a fusion protein together with clover yellow virus Nuclear Inclusion a (NIa), the NIa component serving to autolyze the fusion protein after expression. This system can be used to express a novel polypeptide which we have designated KM31-7 protein and which is capable of reducing dichloroindophenol and reduced glutathione. This polypeptide is useful in the treatment of disorders caused by oxidative stress.

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