Expression vectors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/85 (2006.01) C12N 15/11 (2006.01) C12N 15/79 (2006.01) C12N 15/867 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2413156

The present invention provides novel regulatory elements and vectors for the expression of one or more proteins in a host cell. The present invention also provides methods for espressing on or more proteins, such as antibodies, in a host cell. These methods utilize the novel regulatory elements and vectors of the present invention for the expression of proteins in a host cell. The host cells are used for producing various protein products, including but not limited to pharmaceutical proteins, antibodies, variants of proteins for use in screening assays, and for direct use in high throughput screening.

La présente invention porte sur de nouveaux vecteurs et éléments régulateurs de l'expression d'une ou plusieurs protéines dans une cellule hôte. L'invention porte également sur des procédés d'expression d'une ou plusieurs protéines telles que des anticorps dans une cellule hôte. Ces procédés utilisent les nouveaux éléments et vecteurs régulateurs de l'expression de protéines dans une cellule hôte. Les cellules hôtes sont utilisées pour produire divers produits protéiniques, notamment mais pas exclusivement, des anticorps, des variants de protéines destinés à être utilisés dans des méthodes de criblage, et directement dans le criblage à haut rendement.

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