Expression vectors and cell lines expressing vascular...

A - Human Necessities – 61 – K

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Details

A61K 38/18 (2006.01) A61K 38/19 (2006.01) C07K 14/475 (2006.01) C07K 14/49 (2006.01) C07K 14/52 (2006.01) C07K 16/22 (2006.01) C12N 5/10 (2006.01) C12N 15/18 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2315977

This invention relates to expression vectors comprising VEGF-D and its biologically active derivatives, cell lines stably expressing VEGF-D and its biologically active derivatives, and to a method of making a polypeptide using these expression vectors and host cells. The invention also relates to a method for treating and alleviating melanomas or tumors expressing VEGF-D and various diseases.

Cette invention concerne des vecteurs d'expression qui comprennent le facteur de croissance endothélial vasculaire D ainsi que ses dérivés ayant une action biologique. Cette invention concerne également des lignées cellulaires qui expriment de manière stable le facteur de croissance endothélial vasculaire D ainsi que ses dérivés ayant une action biologique. Cette invention concerne en outre un procédé de production d'un polypeptide à l'aide de ces vecteurs d'expression et de cellules hôtes. Cette invention concerne enfin un procédé permettant de traiter et de réduire les mélanomes ou les tumeurs exprimant le facteur de croissance endothélial vasculaire D, ainsi que diverses autres maladies.

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