Expression vectors encoding epitopes of target-associated...

Details Expression vectors encoding epitopes of target-associated... Expression vectors encoding epitopes of target-associated...

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) C07H 21/04 (2006.01) C07K 14/74 (2006.01) C12N 9/02 (2006.01)

Patent

CA 2494806

The invention provides a nucleic acid construct encoding a housekeeping epitope derived from an antigen associated with a target cell. The construct can further include a second sequence encoding a housekeeping epitope or an immune epitope. The construct can be used as a vaccine against numerous kinds of target cells, including neoplastic cells and cells infected with an intracellular virus.

L'invention concerne une construction d'acide nucléique codant pour un épitope domestique dérivé d'un antigène associé à une cellule cible. Cette construction peut en outre comprendre une seconde séquence codant pour un épitope domestique ou un épitope immunitaire. Ladite construction peut être utilisée comme vaccin contre plusieurs types de cellules cibles, y compris les cellules néoplasiques et les cellules infectées par un virus intracellulaire.

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