Extended chain derivatives of somatostatin and process therefor

Details Extended chain derivatives of somatostatin and process therefor Extended chain derivatives of somatostatin and process therefor

C - Chemistry, Metallurgy

07

K

530/7.26

C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1040624

EXTENDED CHAIN DERIVATIVES OF SOMATOSTATIN AND PROCESS THEREFOR Abstract of the Disclosure Compounds of the formula I or Ia Image (I) R1-Gly-Gly-Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-NH?HCH2SH (Ia) wherein R1 is H-, H-Gly or H-Leu and R2 is H or COOH and pharma- ceutically acceptable salts thereof, are disclosed. The compounds of formulae I and Ia are useful for the management of diabetes and the treatment of scromegaly. Methods for their use are also disclosed. -1-

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