Extended release clonidine formulation

Details Extended release clonidine formulation Extended release clonidine formulation

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 9/22 (2006.01) A61K 9/52 (2006.01)

Patent

CA 2211325

A method of providing a patient needing clonidine with an extended dosage of clonidine over a prolonged period of time. Such method involves administering to the patient an oral dosage unit comprising a homogenous mixture of a therapeutically effective amount of clonidine, about 30 to about 70 percent by weight of one or more cellulose ethers such as hydroxypropyl methylcellulose, and about 30 to about 70 percent by weight of an inert substance such as cornstarch. The oral dosage unit may be contained in a gelatin capsule or in the form of a tablet.

La présente invention concerne un procédé permettant d'apporter, à un patient qui nécessite un apport de clonidine, une quantité thérapeutique de clonidine pendant une période de temps prolongée. Ce procédé consiste à administrer audit patient une unité posologique orale comportant un mélange homogène d'une quantité thérapeutiquement efficace de clonidine, environ 30 à 70 pour cent en poids d'au moins un éther de cellulose tel que de l'hydroxypropylméthyl cellulose, et environ 30 à 70 pour cent en poids d'une substance inerte telle que de l'amidon de maïs. L'unité posologique orale peut être contenue dans une capsule de gélatine ou peut se présenter sous la forme d'un comprimé.

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