A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/50 (2006.01)
Patent
CA 2676650
Provided are pharmaceutical formulations comprising sustained release particles each having an inner core bead comprising an active pharmaceutical ingredient an intermediate coating substantially surrounding the inner core bead, and an outer coating substantially surrounding the intermediate coating comprising a pH independent polymer. Also provided is a pharmaceutical formulation comprising two bead populations wherein each of the first and second bead populations have a different drug release profile. Also provided is a method of preparing an extended release dosage composition comprising one or more bead populations.
Cette invention se rapporte à des formulations pharmaceutiques comprenant des particules à libération prolongée. Chacune des particules comporte une bille à noyau central comprenant un principe pharmaceutique actif, un enrobage intermédiaire qui enveloppe sensiblement ladite bille à noyau central, et un enrobage externe qui enveloppe sensiblement ledit enrobage intermédiaire et qui comprend un polymère indépendant du pH. L'invention concerne également une formulation pharmaceutique comprenant deux populations de billes, le profil de libération pharmacologique de la première population de billes étant différent du profil de libération pharmacologique de la seconde population de billes. L'invention concerne par ailleurs un procédé de préparation d'une composition pharmaceutique à libération progressive comprenant une ou plusieurs populations de billes.
Bhat Pavan
Chattaraj Sarat C.
Shaw Andrew A.
Moffat & Co.
Mylan Pharmaceuticals Inc.
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