A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/24 (2006.01) A61K 9/00 (2006.01) A61K 9/20 (2006.01) A61K 9/50 (2006.01) A61K 9/54 (2006.01) A61K 31/43 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2435305
The invention disclosed in this application relates to an extended release oral pharmaceutical composition containing at least one .beta.-lactam anti- biotic intended for releasing the drug over an extended period upon administration. The pharmaceutical composition is useful for maintaining the desired the therapeutic concentration of active ingredient in blood for extended time periods thus meeting the requirements for effective management of infectious diseases. The pharmaceutical composition is either in the form of a tablet, capsule or dry syrup for reconstitution at the time of administration, releasing the active ingredient as initial dose and maintenance dose at a specific rate. The invention disclosed in this application also relates to a process for formulation of an extended release pharmaceutical composition containing .beta.-lactam antibiotics.
La présente invention concerne une composition pharmaceutique orale à libération lente contenant au moins un antibiotique .beta.-lactame, destinée à libérer le médicament pendant une longue période lors de son administration. Cette composition pharmaceutique convient pour maintenir la concentration thérapeutique souhaitée du principe actif dans le sang pendant de longues périodes, remplissant ainsi les conditions permettant de gérer efficacement des maladies infectieuses. Cette composition pharmaceutique se présente sous forme de cachet, de capsule ou de sirop sec dont la reconstitution liquide se fait au moment de l'administration, et elle libère le principe actif en dose initiale et en dose de maintenance à un débit spécifique. Cette invention concerne aussi un processus de préparation de cette composition pharmaceutique à libération lente contenant des antibiotiques .beta.-lactame.
Khadgapathi Podili
Nannapaneni Venkaiah Chowdary
Pavuluri Venkateswara Rao
Pendyala Rama Rao
Mccarthy Tetrault Llp
Natco Pharma Limited
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