Extended release pharmaceutical tablet of metformin

Details Extended release pharmaceutical tablet of metformin Extended release pharmaceutical tablet of metformin

A - Human Necessities

61

K

A61K 31/155 (2006.01) A61K 9/22 (2006.01) A61K 9/28 (2006.01) A61K 9/32 (2006.01) A61K 9/36 (2006.01)

Patent

CA 2470747

The invention provides an extended release pharmaceutical tablet containing: (i) a core comprising by weight, based on the core weight, about 70% to about 99% metformin and pharmaceutically acceptable excipients; and (ii) a coating permeable to metformin. The extended release tablet of the invention exhibit a dissolution profile such that after about 2 hours, from about 7% to about 60% of the metformin is released; after about 4 hours, from about 15% to about 90% of the metformin is released; after about 8 hours, from about 50% to about 100% of the metformin is released; after about 12 hours, more than about 75% of the metformin is released.

L'invention concerne un comprimé pharmaceutique à libération prolongée contenant: (i) un noyau comprenant en poids, en fonction du poids du noyau, environ 70 % à environ 99 % de metformine et des excipients pharmaceutiquement acceptables; et (ii) un enrobage perméable à la metformine. Ledit comprimé à libération prolongée présente un profil de dissolution qui libère environ 7 % à environ 60 % de metformine après environ 2 heures; environ 15 % à environ 90 % de metformine après environ 4 heures; environ 50 % à environ 100 % de metformine après environ 8 heures; plus de 75 % environ de metformine après environ 12 heures.

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