Extended surface aggregates in the treatment of skin conditions

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/127 (2006.01) A61K 8/55 (2006.01) A61K 31/192 (2006.01) A61Q 19/00 (2006.01)

Patent

CA 2584475

The invention relates to the use of extended surface aggregates (ESAs) comprising at least one first amphipathic component, which is a basic aggregate-forming component, and at least one second amphipathic component, which decreases aggregate sensitivity to physical stress, including stress created by enforced passage of said ESAs through pores with an average pore diameter at least 50 % smaller than the average diameter of the ESAs before said passage, such that the average ESA diameter change induced by such physical stress is reduced by 10 % or more, compared to the diameter change induced by such stress in a reference system comprising just the first or just the second aggregate component, in the manufacture of a pharmaceutical preparation for enduring treatment of pathological mammalian skin conditions, including skin irritation, skin inflammation and/or skin damage after topical application, for modifying skin pigmentation and/or for treatment of skin itch.

L'invention se rapporte à l'utilisation d'agrégats à grande surface (ESA: extended surface aggregates) comprenant au moins un premier composant amphipathique, constituant le composant de base formant l'agrégat, et au moins un second composant amphipathique, qui diminue la sensibilité de l'agrégat aux contraintes physiques, notamment à la contrainte créée par le passage forcé desdits ESA à travers les pores, pour un diamètre moyen des pores inférieur d'au moins 50 % au diamètre moyen des ESA avant ledit passage, de manière à réduire le changement de diamètre moyen des ESA induit par une telle contrainte physique d'au moins 10 % par comparaison à un système de référence comprenant uniquement le premier ou uniquement le second composant de l'agrégat, exposé à une contrainte similaire, pour la production d'une préparation pharmaceutique destinée au traitement de longue durée, par application topique, d'états pathologiques de la peau chez les mammifères, notamment des irritations, des inflammations et/ou des atteintes cutanées, à la modification de la pigmentation de la peau et/ou au traitement des démangeaisons cutanées.

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