C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) A61K 48/00 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12N 15/861 (2006.01) C12N 15/87 (2006.01) C12N 15/88 (2006.01)
Patent
CA 2355066
Methods are provided wherein the survival of an organ transplant is enhanced by introducing into cells of the transplant a nucleic acid molecule that modulates heme oxygenase-I activity therein. Nucleic acid molecules that modulate heme oxygenase-I activity and therefore find use in the described methods include, for example, molecules that encode a polypeptide that itself exhibits heme oxygenase-I activity or antisense oligonucleotides that act to inhibit heme oxygenase-I activity in a cell.
Cette invention concerne des méthodes permettant d'améliorer les chances de survie d'un organe transplanté grâce à l'introduction, dans les cellules de ce transplant, d'une molécule d'acide nucléique qui module l'activité hème oxygénase-I dans ledit transplant. Les molécules d'acides nucléiques qui modulent l'activité hème-oxygénase-I et, par là même, interviennent dans les méthodes susmentionnées, comprennent notamment des molécules codant pour un polypeptide qui possèdent lui-même une activité hème oxygénase-I ou des oligonucléotides anti-sens dont l'action inhibe l'activité hème oxygénase-I dans une cellule.
Buelow Roland
Iyer Suhasini
Woo Jacky
Sangstat Medical Corporation
Smart & Biggar
LandOfFree
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