Extension of cellular lifespan, methods and reagents

Details Extension of cellular lifespan, methods and reagents Extension of cellular lifespan, methods and reagents

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 38/16 (2006.01) A61K 38/45 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2315265

The present invention relates to methods and reagents for extending the life- span, e.g., the number of mitotic divisions, of a cell. In general, the subject method relies on the ectopic expression of the telomerase catalytic subunit EST2, or a bioactive fragment thereof. The subject method is useful both in vivo, ex vivo and in situ.

L'invention porte sur un procédé et des réactifs permettant d'allonger la durée de vie, c.-à-d. le nombre des divisions mitotiques, d'une cellule. Ledit procédé, qui se base d'une manière générale sur l'expression ectopique de la sous-unité catalytique EST2 de la télomérase ou d'un de ses fragments bioactifs, peut s'utiliser in vivo, ex vivo et in situ.

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