Extension of lifespan by overexpression of a gene that...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/53 (2006.01) A61K 31/70 (2006.01) A61K 38/44 (2006.01) A61K 48/00 (2006.01) C12N 9/02 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2273173

The present invention provides a method for prolonging the lifespan of a cell by inserting into that cell a gene encoding a protein that increases reactive oxygen metabolism and expressing the gene. The gene is one that encodes the CuZn superoxide dismutase enzyme (SOD) and the cell is, in particular, a motorneuron. The invention also provides a method for increasing the lifespan of a human or animal, in particular companion animals and livestock, by inserting into the cells of the human or animal, a gene encoding SOD. In particular, the cells of the human or animal where the gene is inserted comprise motorneurons. The invention also extends to vectors for the expression of a SOD gene in a cell and to pharmaceutical compositions comprising the SOD gene or vectors comprising the SOD gene.

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