External plaster containing 4-biphenylyl acetic acid

A - Human Necessities – 61 – L

Patent

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Details

A61L 15/58 (2006.01) A61L 15/24 (2006.01) A61L 15/34 (2006.01) A61L 15/44 (2006.01) A61K 31/192 (2006.01)

Patent

CA 2397537

An aqueous hot melted type adhesive base material containing 4-biphenylyl acetic acid (BPAA) is provided. The adhesive base material contains constant amounts of BPAA and has good drug releasability, so that bioavailability of the drug is enhanced. An analgesic and anti-inflammatory external plaster containing BPAA is also provided. The plaster is obtained by dissolving BPAA into an aqueous hot melted type adhesive base material comprising as essential components a styrene-isoprene-styrene block copolymer, an adhesive resin, an antioxidant, lanolin, and water.

Des préparations d'adhésif du type thermofusible contenant de l'eau qui renferment de l'acide 4-biphénylylacétique (BPAA) à l'état stable, présentent de bonnes propriétés de libération des médicaments par l'adhésif et font preuve d'une biodisponibilité élevée. De manière plus particulière, les timbres transdermiques analgésiques et anti-inflammatoires destinés à un usage externe contenant du BPAA se caractérisent en ce qu'ils sont préparés au moyen d'un mélange de BPAA en tant qu'ingrédient actif et d'une base d'emplâtre adhésif du type thermofusible contenant de l'eau, qui renferme en tant que constituants principaux, un copolymère bloc styrène-isoprène-styrène, une résine donnant du collant, un antioxydant et de l'eau.

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