C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/14 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) C07K 14/38 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) G01N 33/50 (2006.01)
Patent
CA 2528851
The present invention relates to extracellular polypeptides ofAspergillus fumigatus, to fragments of these polypeptides, to compositions comprising such polypeptides and fragments and to exposed domains and epitopes of these polypeptides. The invention also relates to the use of these polypeptides and fragments for immunisation and for production of antibodies, and to antibodies that recognize and bind the polypeptides. Furthermore, the invention relates to methods of identifying binding partners and inhibitors, and to methods of preventing, treating and diagnosingAspergillus infections.
L'invention concerne des polypeptides extracellulaires d'Aspergillus fumigatus, des fragments de ces polypeptides, des compositions renfermant lesdits polypeptides et des fragments correspondants ainsi que des domaines exposés et des épitopes des polypeptides en question. L'invention concerne également l'utilisation des polypeptides et de leurs fragments pour l'immunisation et la production d'anticorps, et des anticorps reconnaissant lesdits polypeptides et se liant à eux. L'invention concerne en outre des procédés relatifs à l'identification de partenaires de liaison et d'inhibiteurs, et des procédés pour la prévention, le traitement et le diagnostic des infections à l'Aspergillus.
Hansen Martin Chr.
Henningsen Jeanette
Joergensen Trine Louise Lund
Roche Andrew
Schrotz-King Petra
Ace Biosciences A/s
Gowling Lafleur Henderson Llp
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