Extracellular histones as biomarkers for prognosis and...

Details Extracellular histones as biomarkers for prognosis and... Extracellular histones as biomarkers for prognosis and...

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 39/395 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2704974

Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.

Des réponses hyper-inflammatoires peuvent conduire à une diversité de maladies incluant une sepsie. Il est maintenant montré que les histones extracellulaires libérées en réponse à une stimulation inflammatoire sont des médiateurs contribuant à un dysfonctionnement endothélial, une défaillance d'organe et la mort durant une sepsie. En tant que telles, elles peuvent être pharmacologiquement ciblées par des inhibiteurs, de même qu'utilisées en tant que biomarqueurs pour le pronostic d'une sepsie et d'autres maladies.

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