Extracellular matrix composite materials, and manufacture...

Details Extracellular matrix composite materials, and manufacture... Extracellular matrix composite materials, and manufacture...

A - Human Necessities

61

L

A61L 27/22 (2006.01) A61F 2/02 (2006.01) A61L 27/36 (2006.01) C12P 21/00 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2536923

Described are preferred extracellular matrix composites including a first extracellular matrix material (12) having a second extracellular matrix material (13) deposited thereon. The preferred materials are made by culturing cells in contact with an extracellular matrix graft material (10) in a fashion to cause the cells to biosynthesize and deposit extracellular matrix components on the material. The cells are then removed to provide the extracellular matrix composite material.

L'invention porte sur des composites préférés matriciels extracellulaires comprenant une premier matériau matriciel extracellulaire sur lequel est déposé un second matériau matriciel extracellulaire. Les matériaux préférés sont obtenus par la mise en culture de cellules en contact avec un matériau greffé matriciel extracellulaire de façon à provoquer la biosynthèse des cellules et le dépôt des composants matriciels extracellulaires sur le matériau. Les cellules sont ensuite retirées pour former le matériau composite extracellulaire.

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