Extracellular matrix materials as vaccine adjuvants for...

A - Human Necessities – 61 – K

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A61K 39/39 (2006.01) A61K 35/23 (2006.01) A61K 35/38 (2006.01) A61K 39/08 (2006.01) A61P 37/04 (2006.01)

Patent

CA 2627364

Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.

L'invention concerne des vaccins et des adjuvants de vaccin utiles dans le traitement et/ou la prévention d'infections et de maladies associées à des agents pathogènes infectieux, tels que le tétanos, ainsi que des maladies associées à des toxines biologiques. L'invention concerne en outre des procédés de préparation d'un adjuvant et du vaccin contenant l'adjuvant. Des procédés sont également fournis pour vacciner/immuniser un animal contre une infection et des maladies associées à des agents pathogènes infectieux, tels que le tétanos, et contre d'autres maladies associées à des toxines biologiques. L'invention concerne également des matériaux d'adjuvants préparés à partir d'un matériau de matrice extracellulaire. Il a été prouve que les adjuvants améliorent l'immunogénicité d'un antigène d'agent pathogène infectieux ou d'un antigène de toxine biologique d'intérêt et donc la survie d'un animal immunisé.

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