C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 39/395 (2006.01) A61P 25/28 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2701846
The present invention relates to the field of neurological disorders and more particularly to the field of Alzheimer's disease. Specifically, the invention provides extracellular targets for Alzheimer's disease selected from the tetraspanin web family and associated proteins. In addition, methods are provided for the use of siRNAs and antibodies against the targets for inhibition of amyloid-beta production and, hence, for the treatment of Alzheimer's disease.
La présente invention concerne le domaine des troubles neurologiques et plus particulièrement la maladie d'Alzheimer. De manière spécifique, l'invention propose des cibles extracellulaires pour la maladie d'Alzheimer sélectionnées parmi la famille toile de tétraspanines et protéines associées. L'invention concerne en outre des méthodes d'utilisation d'ARNsi et d'anticorps dirigés contre les cibles pour inhiber la production de la protéine bêta-amyloïde et, par conséquent, pour traiter la maladie d'Alzheimer.
de Strooper Bart
Wakabayashi Tomoko
Fasken Martineau Dumoulin Llp
Katholieke Universiteit Leuven K.u.leuven R&d
Vib Vzw
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