C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/26 (2006.01) C07K 14/315 (2006.01)
Patent
CA 2759373
The invention relates to Streptomyces koganeiensis ATCC 31394 hyaluronidase having molecular weight of 21.6 kDalton, which has hyaluronidase activity and stability markedly higher than those of the hyaluronidase obtained from such microorganism to date. The invention further relates to a process for the isolation and purification of said hyaluronidase and its use for the preparation of pharmaceutical compositions or as an analytical reagent.
L'invention porte sur la hyaluronidase de Streptomyces koganeiensis ATCC 31394 présentant une masse moléculaire de 21,6 kDalton, qui présente une activité de hyaluronidase et une stabilité nettement supérieures à celles de la hyaluronidase obtenue à partir d'un tel microorganisme à ce jour. L'invention porte en outre sur un procédé pour l'isolement et la purification de ladite hyaluronidase et sur son utilisation pour la préparation de compositions pharmaceutiques ou en tant que réactif analytique.
Caruso Salvatore
Gennari Giovanni
Messina Luciano
Vaccaro Susanna
Fidia Farmaceutici S.p.a.
Kirby Eades Gale Baker
LandOfFree
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