Extracorporeal removal of microvesicular particles

Details Extracorporeal removal of microvesicular particles Extracorporeal removal of microvesicular particles

A - Human Necessities

61

K

A61K 39/00 (2006.01) C12M 1/00 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2644855

The invention described herein teaches methods of removing microvesicular particles, which include but are not limited to exosomes, from the systemic circulation of a subject in need thereof with the goal of reversing antigen-specific and antigen-nonspecific immune suppression. Said microvesicular particles could be generated by host cells that have been reprogrammed by neoplastic tissue, or the neoplastic tissue itself. Compositions of matter, medical devices, and novel utilities of existing medical devices are disclosed.

La présente invention concerne des procédés d'enlèvement de particules microvésiculaires, comprenant non limitativement des exosomes, de la circulation systémique d'un sujet nécessitant un tel traitement dans le but d'inverser une suppression immunitaire antigène-spécifique et non antigène-spécifique. Ces particules microvésiculaires ont pu être générées par des cellules hôtes qui ont été reprogrammées par du tissu néoplasique ou par le tissu néoplasique lui-même. L'invention concerne également des compositions de matière, des dispositifs médicaux, ainsi que de nouveaux usages de dispositifs médicaux existants.

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