Extract of bacterial macromolecules, a process for its...

Details Extract of bacterial macromolecules, a process for its... Extract of bacterial macromolecules, a process for its...

C - Chemistry, Metallurgy

12

P

C12P 21/00 (2006.01) A61K 35/74 (2006.01) A61K 38/16 (2006.01) C07K 1/14 (2006.01) C07K 14/245 (2006.01) C12P 1/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2106854

2106854 9316190 PCTABS00025 A modified bacterial protein-based extract comprising a mixture of acidic bacterial polyanions having a molecular weight of 10,000-1,000,000 and an isoelectric point of 2.5-5.5, wherein the sum of the constituent amino acids represents at least 50 wt % of said extract. Said protein extract is prepared by cultivating bacteria in an aqueous medium, subjecting the bacterial suspension to alkaline extraction and purifying the protein extract. Alkaline extraction is performed in the presence of a dilute aqueous source of OH- ions and at a pH of 11-13, with the pH decrease during said extraction being no greater than 0.4. The resulting protein extract may be used as an active ingredient in a pharmaceutical composition.

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