C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 17/04 (2006.01) A61K 31/7048 (2006.01) A61K 36/63 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2704640
A Fraxinus excelsior seed extract that can be administered for therapeutic treatment of a subject, including a hu-man, by blocking fat synthesis, activating PPAR-alpha, increasing hypoglycemic activity, reducing bodyweight, controlling fasting plasma insulin levels against hyperinsulinemia, and promoting insulin sensitivity and causing a beneficial acute insulinotropic effect. The Fraxinus excelsior seed extract includes, inter alia, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethyli-dene-2-[(6-O-.beta.-D-glucopyranosyl-.beta.-D- glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) methyl ester, commonly called ex-celside A, an isolated compound (2S, 3E, 4S) 2H-Pyran-4-acetic acid-3-ethylidene-2-[(6-O- .beta.-D-glucopyranosyl-.beta.-D- glucopyranosyl)oxy]-3,4-dihydro-5-(methoxycarbonyl) 2-(4-hydroxyphenyl) ethyl ester, commonly called excelside B, and the compounds GI5, GI3, nuzhenide, and oleoside dimethyl ester.
L'invention concerne un extrait de graine de fraxinus excelsior qui peut être administré pour le traitement thérapeutique d'un sujet, y compris d'un humain, en bloquant la synthèse des graisses, en activant l'alpha-PPAR, en augmentant l'activité hypoglycémique, en réduisant le poids corporel, en surveillant les niveaux d'insuline plasmatique à jeun par rapport à l'hyperinsulinisme, en favorisant la sensibilité à l'insuline et en provoquant un effet insulinotropique aigu bénéfique. L'extrait de graine de fraxinus excelsior comprend, entre autres, un composé isolé (2S, 3E, 4S) 2H-pyran-4-acide acétique-3-éthylidène-2-[(6-O-ß-D-glucopyranosyl-ß-D-glucopyranosyl)oxy]-3,4-dihydro-5-(méthoxycarbonyl)méthylester, communément appelé excelside A, un composé isolé (2S, 3E, 4S) 2H-pyran-4-acide acétique-3-éthylidène-2-[(6-O-ß-D-glucopyranosyl-ß-D-glucopyranosyl)oxy]-3,4-dihydro-5-(méthoxycarbonyl)2-(4-hydroxyphényl)éthylester, communément appelé excelside B, et les composés GI5, GI3, nuzhénide et du diméthylester d'oléoside.
Bai Naisheng
Bily Antoine
Dikansky Jacques
He Kan
Ibarra Alvin
Naturex Inc.
Naturex S.a.
Smart & Biggar
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