Extraction of alkaloids

Details Extraction of alkaloids Extraction of alkaloids

C - Chemistry, Metallurgy

07

D

195/60, 260/237.

C07D 519/04 (2006.01)

Patent

CA 1262443

ABSTRACT OF THE DISCLOSURE Alkaloids present in Catharanthus roseus tissue are selectively concentrated by aqueous extraction of ground tissue followed by extraction with organic solvent e.g. ethyl acetate. The resultant concentrate is rich in catharanthine, vindoline and 3',4'-anhydrovinblastine (AVLB). Yield of AVLB is enhanced by addition to the aqueous extraction medium of acid, salt, or hydrogen peroxide and can be further enhanced through the addition of sodium borohydride.

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