Extractive purification of lipopeptide antibiotics

Details Extractive purification of lipopeptide antibiotics Extractive purification of lipopeptide antibiotics

C - Chemistry, Metallurgy

07

K

C07K 1/14 (2006.01) C07K 7/08 (2006.01) C07K 7/56 (2006.01) C07K 9/00 (2006.01) C07K 11/02 (2006.01)

Patent

CA 2433688

The present invention provides a rapid and inexpensive method for extractively isolating acidic lipopeptide antibiotics in high yield and purity. The lipopeptide antibiotics, which can be cyclic depsipeptides or cyclic peptides, are extracted by contacting an aqueous solution of the lipopeptide antibiotic and a divalent metal ion with an organic solvent, and then contacting the organic solvent extract of the lipopeptide antibiotic with acid. Alternatively, an acidic lipopeptide antibiotic is partitioned from an aqueous solution into an organic solvent and is then recovered from the organic solvent.

La présente invention concerne un procédé rapide et économique d'isolation extractive d'antibiotiques lipopeptidiques acides avec un rendement et une pureté élevés. Lesdits antibiotiques lipopeptidiques pouvant être des depsipeptides cycliques ou des peptides cycliques sont extraits par mise en contact d'une solution aqueuse de l'antibiotique lipopeptidique et d'un ion métallique bivalent avec un solvant organique, puis mise en contact de l'extrait de solvant organique de l'antibiotique lipopeptidique avec de l'acide. Dans un autre mode de réalisation, un antibiotique lipopeptidique acide est séparé d'une solution aqueuse dans un solvant organique, puis récupéré à partir du solvant organique.

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