Eye treatments using synthetic thyroid hormone compositions

Details Eye treatments using synthetic thyroid hormone compositions Eye treatments using synthetic thyroid hormone compositions

A - Human Necessities

61

K

A61K 31/27 (2006.01) A61K 9/127 (2006.01) A61K 31/195 (2006.01) A61K 45/06 (2006.01) A61K 47/30 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2260992

The present invention involves the discovery that synthetic thyroid hormones can be used as compositions to reduce intraocular pressure in vivo. Methods of screening synthetic thyroid hormones for effect on intraocular pressure, aqueous pressure, hydraulic conductivity, hyaluronic acid secretion, and extracellular matrix assembly are provided. Methods of treating glaucoma and treating excess intraocular pressure with synthetic thyroid hormones and compositions therefore are also provided.

La présente invention porte sur la découverte qui a été faite selon laquelle les hormones thyroïdiennes synthétiques peuvent être utilisées en tant que compositions visant à réduire la tension intraoculaire in vivo. Elle présente des procédés de criblage des hormones thyroïdiennes synthétiques pouvant avoir des effets sur la tension intraoculaire, la tension de l'humeur aqueuse, la conductivité hydraulique, la sécrétion de l'acide hyluronique et la matrice extracellulaire. Ladite invention porte enfin sur des procédés de traitement du glaucome et d'une tension intraoculaire excessive par l'utilisation d'hormones thyroïdiennes synthétiques et de compositions de celles-ci.

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