F-18 peptides for pre targeted positron emission tomography...

Details F-18 peptides for pre targeted positron emission tomography... F-18 peptides for pre targeted positron emission tomography...

C - Chemistry, Metallurgy

07

K

C07K 5/107 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01) A61M 36/14 (2006.01) C07B 59/00 (2006.01) C07K 1/13 (2006.01) C07K 5/09 (2006.01) C07K 5/10 (2006.01)

Patent

CA 2619941

F-18 radiolabeled peptides are prepared by reacting a peptide comprising a hydroxylamine, a thiosemicarbazide, a hydrazine or a free amine group with 4- [18F]Fluorobenzaldehyde. Specific, non-limiting examples of F-18 radiolabeled peptides are described herein. The labeled peptides are useful, for example, in clinical positron emission tomography.

L'invention concerne des peptides F-18 radiomarqués préparés par réaction d'un peptide comprenant une hydroxylamine, une thiosemicarbazide, une hydrazine ou un groupe amine libre avec 4-[18F]fluorobenzaldehyde. L'invention concerne également des exemple spécifiques non limités depeptides F-18 radiomarqués. On utilise ces peptides marqués, par exemple, dans une tomographie clinique par émission de positrons.

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