F,g,h,i and k crystal forms of imatinib mesylate

Details F,g,h,i and k crystal forms of imatinib mesylate F,g,h,i and k crystal forms of imatinib mesylate

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2628330

The invention relates to the F-crystal form, G-crystal form, H-crystal form, I- crystal form and K-crystal form of the methanesulfonic acid addition salt of 4- (4-methylpiperazin-1-ylmethyl)- N-[4-methyl-3-(4-(pyridin-3-yl)pyrimidin-2- ylamino)phenyl]-benzamide, certain processes for their preparation, pharmaceutical compositions containing these crystal forms, their use in diagnostic methods or for the therapeutic treatment of warm-blooded animals, and their use as an intermediate or for the preparation of pharmaceutical preparations for use in diagnostic methods or for the therapeutic treatment of warm-blooded animals, especially humans.

La présente invention concerne la forme cristalline F, la forme cristalline G, la forme cristalline H, la forme cristalline I et la forme cristalline K du sel d'addition d'acide méthanesulfonique du 4-(4-méthylpipérazin-1-ylméthyl)- N-[4-méthyl-3-(4-(pyridin-3-yl)pyrimidin-2-ylamino)phényl]-benzamide, certains procédés de synthèses desdites formes, des préparations pharmaceutiques contenant ces formes cristallines, leur utilisation dans des méthodes diagnostiques ou pour le traitement thérapeutique d'animaux à sang chaud, et leur utilisation en tant qu'intermédiaires ou pour l'élaboration de préparations pharmaceutiques pouvant être employées dans des méthodes diagnostiques ou pour le traitement thérapeutique d'animaux à sang chaud, en particulier des humains.

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