C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01) C07K 7/08 (2006.01) C07K 16/28 (2006.01)
Patent
CA 2613836
The present invention provides a cell adhesion molecule (CAM), designated FI l receptor (Fl IR), which is a member of the immunoglobulin super family localized on the surface of human platelets, and determined to effect platelet aggregation, secretion, platelet spreading and cellular adhesion. Cloned FI lR cDNA and full length FI lR cDNA and amino acid sequences are provided. Fl lR- antagonists and methods for the prevention and treatment of thrombosis, atherosclerosis, heart attacks, stroke and other clinical disorders involving thrombus formation are also provided.
La présente invention se rapporte à une molécule d'adhésion cellulaire (CAM), désignée récepteur F11 (F11R), qui fait partie de la superfamille des immunoglobulines, est localisée sur la surface de plaquettes humaines, et est destinée à provoquer l'agrégation plaquettaire, la sécrétion plaquettaire, l'étalement plaquettaire et l'adhésion cellulaire. L'invention concerne aussi de l'ADNc de F11R et de l'ADNc pleine longueur de F11R clonés, ainsi que des séquences d'acides aminés. L'invention a également trait à des antagonistes de F11R et à des méthodes permettant de prévenir et de traiter la thrombose, l'athérosclérose, les crises cardiaques, les infarctus et d'autres troubles cliniques faisant intervenir la formation d'un thrombus.
Babinska Anna
Ehrllich Yigal H.
Kornecki Elizabeth
Babinska Anna
Ehrllich Yigal H.
Kornecki Elizabeth
Mcfadden Fincham
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