C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/16 (2006.01) C07K 1/00 (2006.01) C07K 16/10 (2006.01)
Patent
CA 2371929
The crystal structure of the Fab' fragment of Mab 2F5, a potent neutralizer of both laboratory strains and primary clinical isolates of most clades of HIV-1, both uncomplexed and complexed with the largely conserved peptide sequence ELDKWAS of the viral envelope protein gp41, has been elucidated and the characteristics of peptide-protein interactions determined. Having regard to such determination, the peptide-mimetics are constrained in the three- dimensional structure to provide an increased immunogenicity to the epitope sequence.
L'invention porte sur la structure cristalline du fragment Fab de Mab 2F5, puissant agent neutralisant à la fois des souches de laboratoire et des isolats cliniques primaires de la plupart des variantes du VIH-1, aussi bien non complexées que complexées avec la séquence peptidique ELDKWAS fortement conservée de la protéine d'enveloppe virale gp41, dont on à déterminé les caractéristiques des interactions peptide/protéine. Au vu de cette détermination, les mimétiques de peptides subissent des contraintes dans la structure tridimensionnelle, assurant une antigénicité accrue à ladite séquence d'épitope.
Chong Pele
Klein Michel H.
Pai Emil F.
Pedyczak Arthur
Aventis Pasteur Limited
Sim & Mcburney
University Of Toronto
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