Fabrication of soft contact lens and composition therefor

A - Human Necessities – 61 – K

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18/106, 167/153

A61K 9/70 (2006.01) A61L 15/12 (2006.01) A61L 15/44 (2006.01) B29D 11/00 (2006.01) C08F 271/02 (2006.01) G02B 1/04 (2006.01)

Patent

CA 1076477

ABSTRACT OF THE DISCLOSURE A contact lens compositon, having improved dimensional stability, suitable for use in the preparation of a corrective hydrated lens or an eye bandage,comprised polymerized random graft copolymers containing (in the dry state) from 67.2% to 79.3% HEMA; from 14.25% to 35%PVP; from 0.1% to 4.04% EDMA; from 0.1% to 2.5%MA; from 0.1% 5.0% water;from 0 to 4 ppm HQ inhibitor; and from 50 to 250 ppm MEHQ inhibitor. The contact lens com- position contains from 45% to 65% water after hydration. An improved method for shaping, polymerizing, and cutting and hydrating the contact lens com- position is provided. The polymerization is conducted using only a low temperature initaitor, by de-gassing prior to polymerization to remove sub- stantioally all oxygen, and by conduction the initial polymerization reaction at from 23 °C to 30° C for 16 to 30 hours, during which the heat of the reac- tion is continuously absorbed to control the reaction exotherm. A closed, rod-shaped casting mold, lined with a polyester film material, is used and the polymeric rod obtained may be cut, machined and polished to obtain the contact lens composition.Thereafter, hydration is conducted in a buffered 0.85% to 0.9% saline solution, at a pH of 7.0 to 7.1. s

240087

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