A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) A61D 99/00 (2006.01) A61L 27/00 (2006.01) A61L 31/00 (2006.01) A01N 1/02 (2006.01) A61M 1/00 (2006.01) A61M 1/10 (2006.01) A61M 1/14 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2592574
One aspect of the invention provides improved methods for the production of at least substantially cellularly human solid organs and solid tissues in non- human mammalian hosts. Related aspects of the invention provide: transplantation-based methods for obtaining organ and/or tissue-specific gene expression and/or phenotypes with respect to selected cell types and/or at least substantially all cell types of a solid organ or tissue; methods for cellularly reconstituting solid organs and tissues with replacement cells, such as human cells, with respect to selected cell types and/or at least substantially all cell types of an organ or tissue; modified non-human mammals for cellularly reconstituting solid organs and tissues with replacement cells; and the cellularly reconstituted solid organs and tissues. The production of human organs and tissues according to the invention overcomes the limitations associated with xenotransplantation of animal organs and tissues to humans.
Selon un aspect, l'invention concerne des procédés améliorés pour la production d'organes et de tissus humains solides au moins sensiblement sur le plan cellulaire, chez des hôtes mammaliens non humains. Des aspects connexes de l'invention concernent : procédés à base de transplantation pour l'établissement d'une expression génique spécifique aux organes et/ou aux tissus et/ou de phénotypes par rapport à des types de cellules spécifiques et/ou au moins à sensiblement tous les types de cellules d'organe ou de tissu solide ; procédés de reconstitution cellulaire d'organes et de tissus solides avec des cellules de remplacement, du type cellules humaines, par rapport à des types de cellules spécifiques et/ou au moins à sensiblement tous les types de cellules d'un organe ou d'un tissu ; mammifères non humains modifiés pour la reconstitution cellulaire d'organes et de tissus solides avec des cellules de remplacement ; et organes et tissus solides à reconstitution cellulaire. La production d'organes et de tissus humains selon les conditions décrites permet de dépasser les limites associées à la xénotransplantation d'organes et de tissus animaux sur des humains.
Diamond Paul
Moffat & Co.
LandOfFree
Facilitated cellular reconstitution of organs and tissues does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Facilitated cellular reconstitution of organs and tissues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Facilitated cellular reconstitution of organs and tissues will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1557878