Facilitation of ampa receptor-mediated synaptic transmission...

Details Facilitation of ampa receptor-mediated synaptic transmission... Facilitation of ampa receptor-mediated synaptic transmission...

C - Chemistry, Metallurgy

07

D

C07D 285/28 (2006.01) A61K 31/36 (2006.01) A61K 31/40 (2006.01) A61K 31/4015 (2006.01) A61K 31/4025 (2006.01) A61K 31/44 (2006.01) A61K 31/4453 (2006.01) A61K 31/453 (2006.01) A61K 31/454 (2006.01) A61K 31/495 (2006.01) A61K 31/498 (2006.01) A61K 31/535 (2006.01) A61K 31/536 (2006.01) A61K 31/54 (2006.01) A61K 31/549 (2006.01) A61K 31/55 (2006.01) A61K 31/5513 (2006.01)

Patent

CA 2230532

Psychotic symptoms are treated by the administration of drugs which amplify the ability of natural stimulators of AMPA receptors to enhance the mediation of excitatory synaptic response. What is previously known about the activity and effectiveness of these drugs is unrelated to the etiology of psychotic symptoms. The invention finds particular utility in the treatment of schizophrenia.

On traite des symptômes psychotiques par administration de médicaments amplifiant la capacité de stimulateurs naturels de récepteurs de AMPA d'augmenter la médiation d'une réponse synaptique excitative. Ce qu'on sait jusqu'à maintenant concernant l'activité et l'efficacité de ces médicaments est sans rapport avec l'étiologie de symptômes psychotiques. L'invention est particulièrement utile pour traiter la schizophrénie.

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