Factor interacting with nuclear proteins

Details Factor interacting with nuclear proteins Factor interacting with nuclear proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/81 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2188423

The present invention provides a nucleic acid encoding a B-lymphocyte specific activator of octamer site-mediated gene transcription, which interacts with the POU domaine of Oct-1 and Oct-2 in order to activate gene transcription, and the protein encoded by the nucleic acid. In a further aspect of the invention, host cells containing or expressing such nucleic acids are provided, as well as methods of using the nucleic acids and cells transformed therewith.

Cette invention se rapporte à un acide nucléique codant un activateur de la transcription génétique véhiculée par site octamère, activateur qui est spécifique des lymphocytes B et qui agit en interaction avec le domaine POU des protéines nucléaires Oct-1 et Oct-2, afin d'activer la transcription génétique, ainsi qu'à la protéine codée par un tel acide nucléique. Un autre aspect de cette invention se rapporte à des cellules hôtes contenant ou exprimant de tels acides nucléiques, ainsi qu'aux procédés d'utilisation de ces acides nucléiques et aux cellules transformées à l'aide de ces procédés.

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