C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/09 (2006.01) A01K 67/027 (2006.01) C07K 14/03 (2006.01) C07K 16/08 (2006.01) C12M 1/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/569 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2701668
Disclosed are a protein and a gene each of which is a factor involved in the latent infection with a herpesvirus. An antibody against the factor is detected in about 50% of patients suffering from mental disorders, while the antibody is rarely detected in normal persons. A mouse having SITH-1 introduced therein develops bipolar disorder or a depression-like metal disorder. Based on this finding, it becomes possible to provide a method for determining a mental disorder objectively and a mental disorder model animal.
Cette invention concerne une protéine et un gène, chacun d'eux étant un facteur impliqué dans l'infection latente par le virus de l'herpès. Un anticorps dirigé contre le facteur est détecté chez environ 50 % des patients souffrant de troubles mentaux, alors que l'anticorps est rarement détecté chez les personnes normales. Une souris dans laquelle a été introduit le SITH-1 développe des troubles bipolaires ou un trouble mental ressemblant à la dépression. D'après ces résultats, il devient possible de fournir un procédé permettant de déterminer objectivement un trouble mental et un modèle animal du trouble mental.
Kobayashi Nobuyuki
Kondo Kazuhiro
Japan Tobacco Inc.
Robic
Virus Ikagaku Kenkyusho Inc.
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