Factor involved in metastasis and uses thereof

Details Factor involved in metastasis and uses thereof Factor involved in metastasis and uses thereof

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 17/02 (2006.01) A61P 35/00 (2006.01) G01N 33/50 (2006.01) C12N 15/113 (2010.01) C07K 14/47 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2501333

The present invention is related to a nucleic acid coding for a factor involved in a biological process, whereby the process is a PI 3-kinase pathway regulated process, preferably a process selected from the group comprising glucose metabolism, amino acid and glucose deprivation processes, diabetes, wound healing, stress response, apoptosis, metastasis, tumorigenesis, cell migration, cell motility in extracellular matrix and cell growth in extracellular matrix, and the factor is a polypeptide comprising an amino acid sequence according to SEQ ID. NO. 1 or a polypeptide having a sequence according to databank entries gi 9506687 or NP_061931, preferably NP_061931.1.

L'invention concerne un acide nucléique codant pour un facteur impliqué dans un processus biologique dans lequel le trajet de PI 3-kinase est régulé, de préférence, processus sélectionné dans le groupe consistant en métabolisme du glucose, appauvrissement en acides aminés et en glucose, diabètes, guérison de blessures, réaction au stress, apoptose, métastase, tumorigénèse, migration cellulaire, motilité des cellules dans une matrice extracellulaire et croissance des cellules dans également une matrice extracellulaire, ce facteur consistant en un polypeptide comprenant une séquence amino acide représentée par SEQ ID. NO. 1 ou un polypeptide possédant une séquence selon des entrées de base de données correspondant à gi 9506687 ou NP_061931, de préférence, NP_061931.1.

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