Factor ix conjugates with extended half-lives

Details Factor ix conjugates with extended half-lives Factor ix conjugates with extended half-lives

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 7/04 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2722169

The present invention relates to conjugates of Factor IX that have been modified to include a biocompatible polymer moiety. The Factor IX conjugates are substantially free of contamination by Factor IXa. The Factor IX conjugates have improved pharmacokinetic properties, such as increased half-life, which results in dose sparing and less frequent administration.

La présente invention concerne des conjugués de facteur IX qui ont été modifiés pour inclure une partie de polymère biocompatible. Les conjugués de facteur IX sont sensiblement exempts de contamination par le facteur IXa. Les conjugués de facteur IX présentent des propriétés pharmacocinétiques améliorées, comme une demi-vie accrue, qui permettent de limiter les doses et de réduire la fréquence d'administration.

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