Factor ix polypeptide mutant, its uses and a method for its...

Details Factor ix polypeptide mutant, its uses and a method for its... Factor ix polypeptide mutant, its uses and a method for its...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01)

Patent

CA 2737094

Disclosed are a modified FIX (factor IX) polypeptide comprising a leucine, cysteine, aspartic acid, glutamic acid, histidine, lysine, asparagine, glutamine or tyrosine in position 338; pharmaceutical preparations containing said modified FIX polypeptide; a nucleotide sequence coding for the modified FIX polypeptide; and a method for producing the modified FIX polypeptide.

L'invention porte sur un polypeptide FIX (facteur IX) modifié comprenant une leucine, une cystéine, un acide aspartique, un acide glutamique, une histidine, une lysine, une asparagine, une glutamine ou une tyrosine en position 338; sur des préparations pharmaceutiques contenant ledit polypeptide FIX modifié; sur une séquence nucléotidique codante pour le polypeptide FIX modifié; et sur une méthode pour la fabrication du polypeptide FIX modifié.

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