Factor ixa for the treatment of bleeding disorders

Details Factor ixa for the treatment of bleeding disorders Factor ixa for the treatment of bleeding disorders

A - Human Necessities

61

K

A61K 38/36 (2006.01) A61P 7/04 (2006.01)

Patent

CA 2557061

The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.

L'invention concerne une méthode de traitement de troubles de saignement chez un sujet, par l'administration d'une préparation enrichie en facteur IXa. Le facteur IXa peut être produit par l'activation protéolytique du facteur IX produit par recombinaison. L'invention porte également sur une méthode améliorée de production du facteur IXa à partir d'une fraction de plasma, qui permet d'obtenir un produit du facteur IXa ayant une activité de prékallikréine faible ou inexistante, et de réduire ainsi l'incidence des effets secondaires indésirables chez un sujet.

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