Factor vii-derived peptides

Details Factor vii-derived peptides Factor vii-derived peptides

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) C07K 7/06 (2006.01) C07K 14/745 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2164422

The present invention relates to compounds comprising the amino acid sequences of the formulae (IA): -CVNENGGRQYCSD-, (IB): -FCLPAFEGRNCE- and/or (IC): -RCHEGYSLLAGVSCT- as well as peptide fragments thereof, esters, amides, salts and cyclic derivatives thereof, funtional analogues thereof and extended peptide chains carrying amino acids or peptides at the termini of the above sequences or fragments, for use in the prevention or inhibition of binding of tissue factor to FVII.

Cette invention concerne des composés comprenant les séquences d'acides aminés de formules (IA): -CVNENGGCEQYCSD-, (IB): -FCLPAFEGRNCE- et/ou (IC): -RCHEGYSLLADGVSCT- ainsi que les fragments peptidiques de ces derniers, leurs esters, amides, sels et dérivés cycliques, leurs analogues comportant des acides aminés ou des peptides aux terminaux des séquences ou des fragments précités. Ces composés sont utilisés pour prévenir ou inhiber la liaison du facteur tissulaire au facteur VII.

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