Factor vii or viia gla domain variants

Details Factor vii or viia gla domain variants Factor vii or viia gla domain variants

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A61K 38/36 (2006.01) C07K 14/745 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2529828

Gla domain variants of human Factor VII or human Factor VIIa, comprising 1-15 amino acid modifications relative to human Factor VII or human Factor VIIa, wherein a hydrophobic amino acid residue has been introduced by substitution in position 34, or having an amino acid substitution in position 36, or having amino acid substitutions in positions 10 and 32 and at least one further amino acid substitution in a position selected from 74, 77 and 116.

La présente invention concerne des variants du domaine Gla du Facteur VII humain ou du Facteur VIIa humain comprenant entre 1 et 15 modifications d'acides aminés par rapport au Facteur VII humain ou au Facteur VIIa humain, lesquelles modifications comprennent l'introduction par substitution d'un résidu d'acide aminé hydrophobe en position 34, la substitution d'acides aminés en position 36, des substitutions d'acides aminés en positions 10 et 32 et au moins une autre substitution d'acides aminés en position 74, 77 ou 116.

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